Donating plasma is similar to donating blood. A donor will be comfortably reclined in a chair during the actual donation. A needle is placed in one arm and the blood goes through specialized plasmapheresis equipment that separates your plasma from the rest of the blood components. A donor’s red blood cells are then returned to the body using the same needle. All materials that come into contact with a donor’s blood during the plasmapheresis process are sterile and single-use only. During your donation, you will have the use of one arm and may use a handheld device or just relax and watch TV. Learn more about the plasma donation process.